Antibacterial Potential of Noni Fruit Ethanol Extract on Salmonella typhi Bacteria
Salmonella typhi is a bacterium that infects humans a lot and antibiotic resistance has been found. Therefore further research is needed to find a more sensitive antibiotic therapy. This research was conducted to study the antibacterial activity, with noni fruit as the selected plant. Testing for this antibacterial potential was carried out by preparing the test material in the form of ethanol extract from noni fruit which was tested on S. thypi bacteria in vitro. The method used is liquid dilution. The antibacterial potential of the ethanol extract of noni fruit was assessed by looking at the MIC and KBM values. The data obtained were then analyzed using unpaired T-test data analysis. The results of this study indicate that the ethanol extract of noni fruit has antibacterial potential with an average MIC of 4,8 x 103 µg/mL, and the average KBM value is 5,2 x 103 µg/mL, while the MIC and MBC values for chloramphenicol were 7,2 µg/mL. The ethanol extract of noni fruit has very little antibacterial potential on S. thypi in vitro compared to chloramphenicol. The difference between the MIC and the MBC of the ethanol extract of noni fruit was very significant with the MIC and MBC of chloramphenicol as positive controls. Keywords: antibacterial, noni extract, S. thypi, in vitro, chloramphenicol
Advisor I
Dr. Mustofa, Mkes, Apt
Advisor II
dr. H. Syaefudin Ali Akhmad