Toxidynamics of Aminoglycoside Antibiotics

Toxidynamics of Aminoglycoside Antibiotics

Abstract: The aminoglycosides are the mainstay in the treatment of serious gram-negative systemic infections. These are the broad spectrum antibiotics, and can be used for many infections of body systems. A disadvantage of the aminoglycosides is their association with nephrotoxicity, ototoxicity, and neurotoxicity, all of which are associated with elevated serum levels. This article is carried out to give information about mechanisms of toxicities and their pathology, which is highlighted on aspects of biochemistry, functional and structural.

Author: Miladiyah Palace

Toxidynamics of Aminoglycoside Antibiotics

Abstract: The aminoglycosides are the mainstay in the treatment of serious gram-negative systemic infections. These are the broad spectrum antibiotics, and can be used for many infections of body systems. A disadvantage of the aminoglycosides is their association with nephrotoxicity, ototoxicity, and neurotoxicity, all of which are associated with elevated serum levels. This article is carried out to give information about mechanisms of toxicities and their pathology, which is highlighted on aspects of biochemistry, functional and structural.

Author: Miladiyah Palace

Published on : JKKI Volume 2, Number 5 April 2010